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Top 50 Startups in New York City Across 5 Niches in 2025

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Startups in New York City

Why are startups in New York City gaining so much attention? With over hundreds of venture capital firms and a vast consumer market, NYC offers unmatched opportunities. Entrepreneurs find endless possibilities, from tech innovation to healthcare breakthroughs. The city’s thriving ecosystem, supportive programs, and access to diverse talent make it a hotspot for dreamers and doers alike. Whether you want to launch a Fintech company or dive into AI, the opportunities here are limitless. Curious about the best niches to explore? Keep reading, and discover why NYC is the ultimate playground for startups in 2025!

Why should you consider startups in NYC and what is their importance?

Startups in New York City enjoy unmatched advantages, starting with access to capital. The city hosts over 300 venture capital firms ready to invest in new ideas. In 2023, NYC startups raised $10.7 billion, showing its strong financial environment. New York also claimed over 15% of US fundraising, proving its growing importance.

The city’s large population, exceeding 8 million, offers a huge market for products and services. If NYC were a country, it would be the 10th largest economy globally, with a gross metropolitan product of $1.66 trillion. This vast consumer base allows startups to test and grow quickly.

NYC’s startup ecosystem is also incredibly supportive. The NYC Economic Development Corporation (NYCEDC) provides programs like the Venture Access Alliance, which ensures diverse funding opportunities. With over 25,000 tech-enabled startups, the city thrives on collaboration and innovation.

Additionally, NYC’s diverse culture and top educational institutions create a highly skilled talent pool. Startups benefit from professionals in technology, finance, and media, driving creativity and growth.

Quick Facts About NYC Startups:

  • Funding: NYC startups raised $10.7 billion in 2023.
  • Market Size: NYC’s economy is worth $1.66 trillion.
  • Startup Growth: Over 25,000 tech-enabled startups operate here.
  • Job Creation: The tech sector added 114,000 jobs between 2010 and 2021.

NYC combines funding, talent, and market opportunities, making it a dream city for entrepreneurs. Ready to start? NYC has everything you need to succeed!

5 High-Growth Niches for Startups in New York City

  1. Fintech

The fintech sector is booming and is expected to reach a market size of $340 billion by 2025. With a growth rate of 16.5% annually from 2024 to 2032, Fintech is quickly changing the way people manage money. The rise of smartphones and digital payments is driving this growth. Also, venture capital investments in Fintech startups in New York City are projected to surpass $100 billion every year. As a result, more people will use digital financial services, with 3 billion users expected by 2025. This rapid growth is reshaping the financial landscape.

  1. Artificial Intelligence (AI)

Artificial Intelligence (AI) is also making waves. In 2025, new advancements like Agentic AI will allow systems to make independent decisions. This will improve automation in industries like healthcare and customer service. For example, AI will predict patient needs and even detect fraud on its own. This shift is boosting investor confidence, with sectors like Health Tech seeing revenue multiples of up to 28.8x.

  1. Healthcare

In the Healthcare sector, AI adoption is increasing, and revenue multiples are growing from 6.5x in 2024 to 7.3x in 2025. AI is helping doctors with diagnostics, patient monitoring, and drug discovery, which improves patient care while cutting costs. As healthcare demands rise, AI’s role becomes even more critical in enhancing care and efficiency.

  1. Cybersecurity

Cybersecurity is becoming more vital. With digital transformation, businesses need stronger protections. The cybersecurity market will grow from a 15.5x revenue multiple in 2024 to 21.3x in 2025. Companies, including startups in New York City, are investing heavily to safeguard their digital assets against growing threats.

  1. Internet of Things (IoT)

The Internet of Things (IoT) is expanding rapidly. The global IoT market could reach $1 trillion by 2026. Industries like manufacturing and healthcare are adopting IoT to boost efficiency and make smarter decisions. These trends show how technology is reshaping industries, including startups in New York City, where innovation is at the forefront.

Top 10 startups in NYC from the 5 niches mentioned earlier

Top 10 Fintech Startups in New York City

NameFounding YearDescription
Gusto2011All-in-one platform for payroll, benefits, and team management, helping over 100,000 businesses.
Focuses on diversity, inclusivity, and personalized support for businesses.
Popular among fintech startups in NYC for its user-friendly and simplified HR management features.
Novo2016Fee-free, transparent business banking designed for small business owners, freelancers, and entrepreneurs.
Integrates with existing tools for seamless financial management, free from hidden fees or upselling.
Highly beneficial for NYC startups due to its integration and hassle-free banking experience.
AlphaSense2011Uses AI and Machine Learning for powerful search results and valuable insights.
Helps global companies make informed decisions and stay ahead of the competition.
Popular with NYC startups, offering data-driven insights for smarter business decisions.
TaxBit2018Automates crypto tax management, tracking transactions in any currency and ensuring tax compliance.
Saves time and simplifies the tax process for crypto businesses.
Ideal for NYC-based crypto startups looking for a seamless tax management solution.
Finch2020Standardizes employment data infrastructure, connecting business and employee data systems.
Promotes innovation and economic growth by streamlining data access.
Popular with NYC tech and data startups for managing and making sense of employment data.
Ripple2013Uses blockchain technology to make financial transactions faster, more cost-effective, and transparent.
Active in over 50 countries, providing global value transfer solutions.
NYC startups leverage Ripple’s technology for efficient financial transactions, scaling quickly without delays.
Nova Credit2016Converts international credit histories into U.S. credit scores, providing financial access for immigrants.
Bridges cross-border credit reporting gaps, helping newcomers integrate into the U.S. financial system.
NYC startups serving immigrant communities use Nova Credit’s services for smoother financial integration.
Chainalysis2014Provides advanced compliance and investigation tools to build trust in blockchain technology.
Partners with law enforcement and businesses to fight fraud and ensure blockchain transparency.
Used by NYC fintech startups in the blockchain and crypto sectors to prevent fraud and ensure regulatory compliance.
Coast2020Offers a flexible payment card for fleet and fuel payments, simplifying spending and tracking.
Reduces administrative tasks and enhances financial control for businesses.
Ideal for NYC startups with fleet operations or fuel management needs, improving payment processes.
Rho2018Centralizes banking, payments, and expenses, automating workflows to simplify financial management.
Reduces friction and offers a unified solution for managing finances efficiently.
Adopted by NYC finance and tech startups to streamline operations and improve business management.

Top 10 AI Startups in New York City

NameFounding YearDescription
Mashgin2014Uses advanced 3D computer vision and deep learning for fast checkout systems.
Trusted by major clients like NFL, MLB, and Aramark for stadium and retail operations.
Reduces wait times and boosts customer satisfaction, making it a top AI startup in NYC.
Labelbox2018Unlocks the potential of generative AI and Large Language Models (LLMs) for businesses.
Combines human oversight with automation to drive smarter data decisions.
Streamlines AI product development, making it essential for businesses in NYC.
6sense2013Uses intent data to predict buyer behavior and optimize sales and marketing strategies.
Helps businesses target the right prospects at the right time for better revenue.
Recognized as one of the rising AI startups in NYC for its innovative B2B approach.
Dataiku2013Makes AI and data analytics accessible to both technical and non-technical teams.
Trusted by over 500 companies for tasks like fraud detection and supply chain optimization.
One of NYC’s most popular AI startups, promoting data-driven decisions across industries.
AlphaSense2011Enhances business research with an AI-powered search engine using Natural Language Processing.
Helps companies quickly find key insights for faster, more informed decisions.
Leading NYC startup offering tools to navigate complex data and competitive markets.
Instabase2012Transforms enterprise workflows by integrating apps for tasks like income verification and claims processing.
Streamlines operations, improving efficiency across industries.
A significant NYC startup redefining business operations with simplified processes.
Collibra2008A cloud-based platform that helps organizations make better data-driven decisions.
Connects IT teams with business teams to turn data into a strategic asset.
A standout NYC startup empowering global companies to leverage data for competitive advantage.
Ambient.ai2017Uses AI and computer vision to enhance physical security by detecting threats in real-time.
Reduces false alarms by 95%, providing data-driven security solutions.
A top NYC AI startup reshaping how businesses protect their assets with intelligent security.
SoundHound2005Leader in voice interaction technology, combining speech-to-meaning and music recognition.
Offers the Houndify platform for developers to create voice-enabled devices.
A pioneering NYC startup advancing voice-tech innovation.
Textio2014Analyzes and improves workplace language to promote inclusive communication.
Helps eliminate social biases in recruiting and performance management.
A leading NYC startup changing how companies approach internal communication and diversity efforts.

Top 10 Healthcare/Digital Healthcare Startups in New York City

NameFounding YearDescription
Spruce Health2013All-in-one communication platform for healthcare providers.
Ensures HIPAA-compliant telemedicine, secure messaging, and workflow automation.
Over 50K+ 4.9-star reviews, simplifying healthcare communication for better efficiency.
Ribbon Health2016API-powered data on doctors, insurance plans, and costs for healthcare consumers.
Helps users find the best providers and affordable healthcare solutions.
Simplifies health decisions, empowering consumers to make smarter choices.
Iterative Health2017AI and machine learning technology for accurate inflammatory bowel disease (IBD) diagnosis.
Optimizes clinical trials and improves GI condition treatment outcomes.
Revolutionizing gastroenterology, trusted by healthcare providers for better patient care.
Garner Health2019Connects employees with top-quality healthcare providers for better experiences.
Reduces healthcare costs for employers while improving employee satisfaction.
One of the most impactful healthcare startups in New York City.
Helix2015Personalized genomics offering DNA sequencing and storage for health insights.
Helps users personalize health and wellness plans based on their genetic information.
Leading the charge in health innovation with one of the largest sequencing labs.
Elaborate2021Bridges the gap between doctors and patients with integrated health data delivery.
Provides personalized health insights through Electronic Medical Records (EMRs).
Supported by leading investors and industry veterans to improve patient care.
Frame2021Concierge care for fertility journeys, offering telemedicine and 1:1 coaching.
Founded by a couple who faced fertility challenges, providing a personalized experience.
Improves chances of success with expert support tailored to individual needs.
Fitnescity2019Wellness testing platform providing consumer-facing tests and personal health analytics.
Partners with local labs and clinics to make wellness testing accessible.
Rapidly growing into the largest wellness testing platform for informed health decisions.
Audicus2012Disrupts the hearing aid market with affordable, custom-programmed devices.
Eliminates middlemen to deliver high-quality hearing aids at lower prices.
Innovative healthcare startup empowering people to access hearing solutions easily.
Suventure2012Offers high-quality IT services and digital strategies to global clients.
Specializes in industries like media, healthcare, and e-commerce.
Trusted partner for businesses looking to innovate and scale with next-gen technologies.

Top 10 Cybersecurity Startups in New York City

NameFounding YearDescription
Netskope2012Creates a new cloud-based perimeter to protect data, cloud, and network security.
An award-winning work culture focused on openness, collaboration, and a supportive environment.
Helps businesses stay safe in the digital world with advanced cloud security.
HYPR2014Known as “The Passwordless Company®,” offering secure, password-free authentication.
Combines smart card-level security with smartphone convenience for faster logins.
Ideal for businesses seeking both high security and speed in authentication.
DataDome2015Specializes in SaaS bot protection using AI and machine learning.
Provides real-time protection for e-commerce and classified sites from cyberattacks.
Offers an easy-to-use solution with a simple dashboard for monitoring and blocking bots.
Panther Labs2018A next-gen security platform designed for the cloud-first world.
Provides scalable cybersecurity solutions to combat emerging threats.
Offers reliability and transparency to help businesses protect cloud-based data.
Sweep3602021Combines AI with cybersecurity through its personal cyber expert, NERD.
Backed by top venture capitalists to change digital safety with innovative solutions.
Helps businesses stay protected from modern cyber threats using smart technologies.
Cyberhaven2016A leader in Data Detection and Response (DDR) focused on preventing data theft.
Protects sensitive information like source codes, financial data, and customer records.
Tools designed to guard against internal and external threats, ensuring compliance and security.
Sagetap2019Revolutionizes software discovery by focusing on the right product-market fit.
Provides tech buyers with more control and connects startups with market opportunities.
Backed by top investors, offering real solutions to businesses and buyers.
Ledger2014Provides top security for crypto assets through hardware wallets.
Ensures digital currencies are safe by keeping private keys separate from vulnerable devices.
Uses a proprietary operating system for unmatched protection in securing crypto.
Myriad3602003Offers a complete range of IT solutions, including security, networking, and cloud services.
Combines engineering expertise with global logistics to enhance business IT strategies.
Trusted by startups to improve IT infrastructure and streamline business operations.
Private Machines2011Focuses on anti-tamper and encryption technology for cloud workloads.
Offers FIPS-certified ENFORCER SRX1 server for the highest level of security.
Ensures sensitive information remains private and secure, even under physical or legal threats.

Top 10 IoT Startups in New York City

NameFounding YearDescription
Motive2013Provides AI-driven technology solutions for over 1 million drivers and 100,000+ businesses.
Enhances safety and operational efficiency with products like driver safety systems, GPS tracking, and ELD compliance.
Serves industries such as trucking, construction, and logistics with real-time data insights.
C3.ai2009Offers enterprise AI software for accelerating digital transformation across industries.
Includes pre-built applications for predictive maintenance, fraud detection, and energy management.
Improves operational efficiency and reduces costs through data-driven insights.
Augury2011Revolutionizes machine health with real-time insights into industrial equipment performance.
Helps businesses reduce downtime, optimize operations, and ensure reliability.
Benefits industries relying on critical machinery, improving efficiency and minimizing disruptions.
RapidSOS2012Connects devices to emergency response systems to deliver life-saving data.
Provides vital information like location and medical profiles to over 3,500 communication centers.
Transforms emergency responses with accurate data for better decision-making during critical situations.
Oden Technologies2014Empowers manufacturers with advanced analytics and machine learning for optimized operations.
Minimizes waste and improves efficiency with data-driven insights.
Helps companies embrace sustainable, competitive solutions in the fourth industrial revolution.
Twin Health2018Uses IoT, AI, and medical science to reverse chronic diseases like diabetes.
Offers personalized health recommendations through patented Whole Body Digital Twin™ technology.
Improves overall well-being with data-driven advice for better health management.
Safari AI2018Uses computer vision and IP cameras to measure critical physical activities.
Provides automated data insights to industries like transportation, retail, and hospitality.
Helps businesses improve operational efficiency and decision-making with real-time data.
Canary Connect2014Specializes in smart home security solutions with user-friendly devices and platforms.
Offers connected, secure, and efficient physical spaces through real-time alerts.
Provides peace of mind to users by monitoring homes with easy-to-use security systems.
US Mobile2014Transforms wireless connectivity with customizable plans and AI-driven savings.
Offers flexibility in 4G and 5G network connectivity for a wide range of devices.
Empowers customers with AI-powered insights to save on costs and choose optimal plans.
Kwant.ai2018Uses AI and low-power sensors to enhance safety and productivity on construction sites.
Provides predictive analytics and real-time data to mitigate risks and improve efficiency.
Promotes a safety-first culture by offering valuable insights for a safer work environment.

Conclusion

Startups in New York City offer endless opportunities for growth and innovation. With its vast resources, supportive ecosystem, and diverse market, success is within reach. Whether you dream of launching a tech company or a creative venture, NYC is the perfect place to start. Are you ready to take the leap? Begin your journey today and make your startup story one for the ages. Success in NYC awaits!

Tejas Tahmankar

FAQs

  1. Which US city has the most startups?

San Francisco is known for having the most startups in the US. Its thriving tech ecosystem and venture capital funding make it a hotspot for entrepreneurs. The city’s innovation and strong business network provide the perfect environment for new ventures. It’s a leading city in the startup world.

  1. Which business is most profitable in New York?

Real estate is the most profitable business in New York. The city’s high demand for both residential and commercial spaces drives massive returns. Investors in property development, leasing, and management are seeing consistent growth. New York’s real estate market remains strong and competitive.

  1. Why is New York full of opportunities?

New York is full of opportunities due to its dense population and thriving business environment. With over one million businesses and countless corporations, there’s always room for new startups. The city’s infrastructure and remote work options make it ideal for growing companies. It fosters a culture of innovation and growth.

  1. What are the benefits of a startup in NYC?

Startups in NYC benefit from various tax exemptions, including MCTMT and real estate transfer tax exemptions. Entrepreneurs also get sales tax credits and telecommunication excise tax credits. These incentives help reduce operational costs and encourage business growth. NYC provides a supportive tax environment for startups.

  1. Where are most startups located in NYC?

Most startups in New York City are located in Brooklyn. The borough has become a hub for entrepreneurs, offering affordable office spaces and creative environments. Its proximity to Manhattan attracts a diverse talent pool. Brooklyn fosters a thriving startup culture, making it ideal for new ventures.